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Phthalides from the rhizome of Ligusticum wallichii

1984; Elsevier BV; Volume: 23; Issue: 9 Linguagem: Inglês

10.1016/s0031-9422(00)84965-1

1873-3700

Wang Pu-shan, Gao Xuanliang, Yixiong Wang, Yoshiyasu Fukuyama, Iwao Miura, Michiharu Sugawara,

Natural product bioactivities and synthesis

Three phthalides, 3-butylidene-7-hydroxyphthalide, and cis and trans-6,7-dihydroxyligustilides, along with a dimeric phthalide wallichilide have been isolated from the hot water extract of the rhizome of Ligusticum wallichii. Their structures were established mainly on the basis of spectroscopic data. 3-Butyl-4,5-dihydro-3-hydroxy phthalide and adenosine were identified as active principles of the extract which are responsible for increase of coronary blood flow in the dog heart.