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A Palladium‐Catalyzed Regiospecific Synthesis of N ‐Aryl Benzimidazoles

2007; Wiley; Volume: 46; Issue: 39 Linguagem: Inglês

10.1002/anie.200702542

1521-3773

Nan Zheng, Kevin W. Anderson, Xiaohua Huang, Hanh Nho Nguyen, Stephen L. Buchwald,

Catalytic Cross-Coupling Reactions

Highly tolerated: A catalytic method employing [Pd2(dba)3] and XPhos or RuPhos permits the efficient synthesis of N-aryl benzimidazoles in regioisomerically pure form starting from ortho-haloanilides (see scheme), and tolerates a wide range of functional groups. dba=trans,trans-dibenzylideneacetone. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702542_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.