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Protective effect of GABA and sodium valproate on stress-induced gastric lesions in guinea-pigs

1985; Oxford University Press; Volume: 37; Issue: 9 Linguagem: Inglês

10.1111/j.2042-7158.1985.tb05114.x

2042-7158

F.J. Miñano, J.S. Serrano, José Antonio Durán, Manuel Sancibrián,

Biochemical Analysis and Sensing Techniques

gamma-Aminobutyric acid (GABA) and sodium valproate (VPA) inhibit the formation of stress-induced gastric ulcers in guinea-pigs. The present study was conducted to evaluate the effect of these drugs on the development of cold- and restraint-induced gastric ulcers in guinea-pigs. In control saline-pretreated animals, a 3 h exposure to cold and restriction resulted in the production of gastric ulcers in 9 out of 10 animals. GABA (200 mg kg-1 oral, i.p.) completely prevented the development of gastric ulcers. VPA (100 and 200 mg kg-1 i.p.) exerted no significant effects on the development of gastric ulcers. GABA (100 mg kg-1 oral and i.p.) and VPA (oral) also exhibited partially protective activity. It is suggested that GABA may participate in a physiological modulation of the gastric mucosal barrier, by increasing its resistance to stress-induced lesions.