Interactive Web Simulation for Propofol and Fospropofol, a New Propofol Prodrug
2008; Lippincott Williams & Wilkins; Volume: 106; Issue: 3 Linguagem: Inglês
10.1213/ane.0b013e3181614fae
ISSN1526-7598
AutoresSinan Yavas, David Lizdas, Nikolaus Gravenstein, Samsun Lampotang,
Tópico(s)Intensive Care Unit Cognitive Disorders
ResumoIn Brief Using pharmacokinetic and pharmacodynamic data published in the scientific literature, we have developed interactive on-line simulations to model administration of propofol and fospropofol, a new water-soluble prodrug formulation of propofol. The prodrug formulation of fospropofol leads to a delayed onset to peak concentrations of propofol. A comparison simulation that overlays administration of fospropofol and propofol allows clinicians to understand the differences of administering fospropofol and traditional propofol. The simulations have the added advantage of allowing for differences among patients documented in test studies and the use of different models. IMPLICATIONS: A new website demonstrates the pharmacokinetics and pharmacodynamics of fospropofol and shows how it differs from propofol.
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