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Diabetes Mellitus and Urinary Tract Infection: Epidemiology, Pathogenesis and Proposed Studies in Animal Models

2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 6S Linguagem: Inglês

10.1016/j.juro.2009.07.090

1527-3792

Swaine L. Chen, Sara L. Jackson, Edward J. Boyko,

Gut microbiota and health

No AccessJournal of Urology1 Dec 2009Diabetes Mellitus and Urinary Tract Infection: Epidemiology, Pathogenesis and Proposed Studies in Animal Models Swaine L. Chen, Sara L. Jackson, and Edward J. Boyko Swaine L. ChenSwaine L. Chen Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri , Sara L. JacksonSara L. Jackson Department of Medicine, University of Washington and Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington , and Edward J. BoykoEdward J. Boyko Department of Medicine, University of Washington and Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington View All Author Informationhttps://doi.org/10.1016/j.juro.2009.07.090AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We reviewed the current state of knowledge about urinary tract infection in patients with diabetes from the clinical and basic science perspectives. We identified key knowledge gaps and areas for further research. Materials and Methods: We performed a focused literature search on certain topics, including clinical studies related to etiology and pathophysiology of urinary tract infection in patients with diabetes, urinary tract infection studies in animal models of diabetes and basic science studies of the molecular mechanisms of urinary tract infection. Results: Individuals with diabetes are at higher risk for urinary tract infection. Increased susceptibility in patients with diabetes is positively associated with increased duration and severity of diabetes. Clinical epidemiological data identifying mechanisms of increased urinary tract infection susceptibility in patients with diabetes are generally lacking and indicate only that urinary tract infections in women with and without diabetes are qualitatively similar in bacterial etiology and morbid sequelae. Existing animal models for diabetes have not been well characterized for urinary tract infection research. The increased incidence, prevalence and severity of urinary tract infection in patients with diabetes argue for aggressive antibacterial chemotherapy but novel therapies resulting from urinary tract infection research in nondiabetic animal models are still not available. Conclusions: Future clinical investigations of urinary tract infection in patients with diabetes should focus on how the disease differs from that in patients without diabetes, notably on the role of glycosuria and urinary tract infection risk. Basic science research priorities for urinary tract infection in patients with diabetes should emphasize further development of diabetic animal models for urinary tract infection research and clinical translation of known important virulence determinants into new therapies. References 1 : Risk of urinary tract infection and asymptomatic bacteriuria among diabetic and nondiabetic postmenopausal women. Am J Epidemiol2005; 161: 557. Google Scholar 2 : Diabetes and the risk of acute urinary tract infection among postmenopausal women. Diabetes Care2002; 25: 1778. Google Scholar 3 : Urinary tract infections in postmenopausal women: effect of hormone therapy and risk factors. Obstet Gynecol2001; 98: 1045. 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Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited byWerneburg G, Hettel D, Lundy S, Adler A, De S, Mukherjee S, Rackley R, Shoskes D and Miller A (2023) Ureteral Stents Harbor Complex Biofilms With Rich Microbiome-Metabolite InteractionsJournal of Urology, VOL. 209, NO. 5, (950-962), Online publication date: 1-May-2023.Lenherr S, Clemens J, Braffett B, Cleary P, Dunn R, Hotaling J, Jacobson A, Kim C, Herman W, Brown J, Wessells H and Sarma A (2016) Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDICJournal of Urology, VOL. 196, NO. 4, (1129-1135), Online publication date: 1-Oct-2016. Volume 182Issue 6SDecember 2009Page: S51-S56 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsurinary tract infectionsdiabetes complicationsdiabetes mellitusexperimentaladhesinsEscherichia coligenomic islandsMetrics Author Information Swaine L. Chen Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri More articles by this author Sara L. Jackson Department of Medicine, University of Washington and Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington More articles by this author Edward J. Boyko Department of Medicine, University of Washington and Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington More articles by this author Expand All Advertisement PDF downloadLoading ...