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Inhibition of Retinoic Acid Synthesis and Its Implications in Fetal Alcohol Syndrome

1991; Wiley; Volume: 15; Issue: 3 Linguagem: Inglês

10.1111/j.1530-0277.1991.tb00560.x

1530-0277

Wendy J. Keir,

Folate and B Vitamins Research

Alcoholism: Clinical and Experimental ResearchVolume 15, Issue 3 p. 560-564 Inhibition of Retinoic Acid Synthesis and Its Implications in Fetal Alcohol Syndrome Wendy J. Keir, Corresponding Author Wendy J. Keir Alcohol Research Center, Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado.Reprint requests: Wendy J. Keir, Ph.D., Alcohol Research Center, Department of Pharmacology, Box C-236, University of Colorado Health Sciences Center. 4200 East 9th Avenue, Denver, CO 80262.Search for more papers by this author Wendy J. Keir, Corresponding Author Wendy J. Keir Alcohol Research Center, Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado.Reprint requests: Wendy J. Keir, Ph.D., Alcohol Research Center, Department of Pharmacology, Box C-236, University of Colorado Health Sciences Center. 4200 East 9th Avenue, Denver, CO 80262.Search for more papers by this author First published: June 1991 https://doi.org/10.1111/j.1530-0277.1991.tb00560.xCitations: 25AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Reference 1 Harbison RD: Teratogens, in JD Doull, CD Klaassen, MO Amdur, (eds): Casarett and Doull's Toxicology: The Basic Science of Poisons. New York Macmillan Publishing Co, Inc, 1980, pp 158–175. 2 Jones KL, Smith DW, Ulleland, CN, Streissguth AP: Pattern of malformations in offspring of chronic alcoholic mothers. Lancet 1: 1267–1271, 1973. 3 Lemoine P, Harrousseautt H, Borteyru JP, Menuet JC: Les en- fants de parents alcoholiques: Anomalies observees a propos de 127 cas. Quest Med 21: 467–482, 1968. 4 Altman B: Fetal alcohol syndrome. J Pediatr Opthalmol 13: 255–258, 1976. 5 Mulvihill JJ, Yeager AM: Fetal alcohol syndrome. Teratology 13: 345–348, 1976. 6 Mulvihill JJ, Klimas JT, Stokes DC, Risemberg HM: Fetal alcohol syndrome: Seven new cases. Am J Obstet Gynecol 125: 937–941, 1976. 7 Palmer RH, Ouellette EM, Warner L, Leichtman SR: Congenital malformations in offspring of a chronic alcoholic mother. Pediatrics 53: 490–494, 1974. 8 Shaywitz SE, Cohen DJ, Shaywitz BA: Behavior and learning difficulties in children of normal intelligence born to alcoholic mothers. J Pediatr 96: 978–982, 1980. 9 Clarren SK, Smith DW: The fetal alcohol syndrome: A review of the world literature. N Engl J Med 298: 1063–1067, 1978. 10 Rosett HL, Weiner L, Edelin KC: Strategies for prevention of fetal alcohol effects. Obstet Gynecol 57: 1–7, 1981. 11 Christoffel KK, Salsfsky I: Fetal alcohol syndrome in dizygotic twins. J Pediatr 87: 963–967, 1975. 12 Collins E, Turner G: Six children affected by maternal alcoholism. Med J Aust 2: 606–608, 1978. 13 DeBeukalaer MM, Randall CL, Stroud DR: Renal anomalies in the fetal alcohol syndrome. J Pediatr 91: 759–760, 1977. 14 Oulette EM, Rosett HL, Rosman NP, Weiner L: The adverse effects on offsspring of maternal alcohol abuse during pregnancy. N Eng J Med 297: 528–530, 1977. 15 Church MW, Holloway JA: Effects of prenatal ethanol exposure on the postnatal development of the brainstem auditory evoked potential in the rat. Alcohol Clin Exp Res 8: 258–265, 1984. 16 Streissguth AP, Herman CS, Smith DW: Intelligence, behavior, and dysmorphogenesis in the fetal alcohol syndrome: A report on 20 patients. J Pediatr 92: 363–367, 1978. 17 Smith DF, MacLeod PM, Tredwell S, Wood B, Newman DE: Intrinsic defects in the fetal alcohol syndrome: Studies on 76 cases from British Columbia and the Yukon Territory. Neurobehav Toxicol Teratol 34: 145–152, 1981. 18 Van Rensburg U: Major skeletal defects in the fetal alcohol syndrome. S Afr Med J 59: 687–688, 1981. 19 Herrmann J, Pallister PD, Opitz JM: Tetraectrodactyly and other skeletal manifestations in the fetal alcohol syndrome. Eur J Pediatr 133: 221–226, 1980. 20 Pauli RM, Feldman PF: Major limb malformations following intrauterine exposure to ethanol: Two additional cases and literature review. Teratology 33: 273–280, 1986. 21 Goldstein G, Arulanantham K: Neural tube defect and renal anomalies in a child with fetal alcohol syndrome. J Pediatr 93: 636–637, 1978. 22 Clarren SK: Neural tube defects and fetal alcohol syndrome. J Pediatr 95; 328–329, 1979. 23 Jones KL, Smith DW: The fetal alcohol syndrome. Teratology 12: 1–10, 1975. 24 Fuster JS, Guell S, Cahuana AB, Garcia-Tornel S: Neural tube defects and fetal alcohol syndrome. J Pediatr 95: 328–329, 1979. 25 Clarren SK, Alvord EC, Sumi SM, Streissguth AP, Smith DW: Brain malformations related to prenatal exposure to ethanol. J Pediatr 92: 64–67, 1978. 26 Qazi Q, Masakawa A, Milman D, McGann B, Chua A, Haller J: Renal anomalies in fetal alcohol syndrome. Pediatrics 63: 886–889, 1979. 27 Jones KL, Smith DW, Streissguth AP, Myrianthopoulous NC: Outcome of offspring of chronic alcoholic women. Lancet 1: 1076–1078, 1974. 28 Olegard R, Sabel K-G, Aronsson M, Sandin B, Johansson PR, Carlsson C, Kyllerman M, Iversen K, Hrbek A: Effects on the child of alcohol abuse during pregnancy: Retrospective and prospective studies. Acta Paediatr Scand 275 (Suppl): 112–121, 1979. 29 Pierog S, Chandavasuo O, Wexler I: Withdrawal symptoms in infants with the fetal alcohol syndrome. J Pediatr 90: 630–633, 1977. 30 Streissguth AP, Landesman-Dwyer S, Martin JC, Smith DW: Teratogenic effects of alcohol in humans and laboratory animals. Science 209: 353–361, 1980. 31 Havlicek V, Childavea R: E.E.G. component of fetal alcohol syndrome. Lancet 2: 477, 1976. 32 Jones KL, Smith DW, Hanson JW: The fetal alcohol syndrome: Clinical delineation. Ann NY Acad Sci 273: 130–137, 1976. 33 Havlicek V, Childiaeva R, Chernick V: EEG frequency spectrum characteristics of sleep states in infants of alcoholic mothers. Neuropediatric 8: 360–373, 1977. 34 Abel EL: Fetal Alcohol Syndrome and Fetal Alcohol Effects. New York , Plenum Press, 1984. 35 Ciba Foundation Symposium 105: Mechanisms of Alcohol Dam age in Utero. London , Pitman, 1984. 36 Schenker S, Becker HC, Randall CL, Phillips DK, Baskin GS, Henderson, GI: Fetal alcohol syndrome: Current status of pathogenesis. Alcohol Clin Exp Res 14: 635–647, 1990. 37 Randall CL, Ekblad U, Anton RF: Perspectives on the pathophysiology of fetal alcohol syndrome. Alcohol Clin Exp Res 14; 807–812, 1990. 38 Pennington SW, Boyd JW, Kalmus GW, Wilson RW: The molecular mechanism of fetal alcohol syndrome (FAS). I. Ethanol-induced growth suppression. Neurobehav Toxicol Teratol 5: 259–262, 1983. 39 Randall CL, Anton RF: Aspirin reduces alcohol induced prenatal mortality and malformations in mice. Alcohol Clin Exp Res 8: 513–515, 1984. 40 Randall CL, Anton RF, Becker HC: Alcohol, pregnancy, and prostaglandins. Alcohol Clin Exp Res 11: 32–36, 1987. 41 Kaufman MH: Ethanol-induced chromosomal abnormalities at conception. Nature 302: 258–260, 1983. 42 Baldwin VJ, MacLeod PM, Benirschkeke K: Placental findings in alcohol abuse. Birth Defects 182: 89–94, 1982. 43 Fisher SL, Atkinson M, Jacobson S, Sehgal P, Burnap J, Holmes E, Teichberg S, Kahn E, Jaffe R. Van Thiel DH: Selective fetal malnutrition: The effect of in vivo ethanol exposure upon in vitro placental uptake of amino acids in the non-human primate. Pediatr Res 17: 704–707, 1983. 44 Snyder AK, Singh SP, Pullen GL: Ethanol-induced intrauterine growth retardation: Correlation with placental glucose transfer. Alcohol Clin Exp Res 16: 167–170, 1986. 45 Schenker S, Dicke JM, Johnson RF, Hays SE, Henderson GI: Effect of ethanol on human placental transport of model amino acids and glucose. Alcohol Clin Exp Res 13: 112–119, 1989. 46 Mukherjee AB, Hogen GD: Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys. Science 218: 700–702, 1982. 47 Tewari S, Noble EP: Ethanol and brain protein synthesis. Brain Res 26; 469–474, 1971. 48 Rawat AK: Effect of maternal ethanol consumption of foetal and neonatal rat hepatic protein synthesis. Biochem J 160: 653–661, 1976. 49 Dow KE, Riopelle RJ: Ethanol neurotoxicity: Effects on neurite formation and neurotrophic factor production in vitro. Science 228: 591–593, 1985. 50 Thadani PV, Schanberg SN: Effects of maternal ethanol ingestion on serum growth hormone in the developing rat. Neuropharmacology 18: 821–826, 1979. 51 Singh SP, Pullen GL, Snyder AK: Effects of ethanol on fetal fuels and brain growth in rats. J Lab Clin Med 112; 704–710, 1988. 52 Witek-Janusek L: Maternal ethanol ingestion: Effect on maternal and neonatal glucose balance. Am J Physiol 251: E178–E184, 1986. 53 Durston AJ, Timmermans JPM, Hage WJ, Hendriks HFJ, DeVries NJ, Heideveld M, Nieuwkoop PD: Retinoic acid causes an anteroposterior transformation in the developing central nervous system. Nature 340: 140–144, 1989. 54 Thaller C, Eichele G: Identification and spacial distribution of retinoids in the developing chick limb. Nature 327: 625–628, 1987. 55 Eichele G: Retinoids and vertebrate limb pattern formation. TIC 5: 246–251, 1989. 56 Roberts AB, Sporn MB: Cellular biology and biochemistry of the retinoids, in MB Sporn, AB Roberts, DS Goodman (eds): The Retinoids, Vol 2. Orlando , Academic Press, 1984, pp 209–286. 57 Giguere V, Ong ES, Segui P, Evans RM: Identification of a receptor for the morphogen retinoic acid. Nature 330: 624–629, 1987. 58 Evans RM: The steroid and thyroid hormone receptor superfamily. Science 186:240: 889–895, 1988. 59 Petkovich M, Brand NJ, Krust A, Chambon P: A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330: 444–450, 1987. 60 Osumi-Yamashita N, Noji S, Nohno T, Koyama E, Doi H, Eto K, Taniguchi S: Expression of retinoic acid receptor genes in neural crest derived cells during development. FEBS 264: 71–74, 1990. 61 Duester G: Human liver alcohol dehydrogenase expression: Retinoic homeostasis and fetal alcohol syndrome, in RR Watson, (ed): Drug and Alcohol Abuse Reviews; Vol 2: Liver Pathology. Clifton , NJ , Humana Press, 1991, in press. 62 Mezey E, Holt PR: The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina. Exp Mol Pathol 15: 148–156, 1971. 63 Van Thiel DH, Gavaler J. Leste R: Ethanol inhibition of vitamin A metabolism in the testes: Possible mechanism of sterility in alcoholics. Science 186: 941–942, 1974. 64 Leo MA, Kim C, Lieber CS: NAD+dependent retinol dehydrogenase in liver microsomes. Arch Biochem Biophys 259: 241–249, 1987. 65 Duester G, Shean ML, McBride MS, Stewart MJ: Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: Implications for regulation of retinoic acid synthesis. Mol Cell Biol 11: 1638–1646, 1991. 66 Biesalski HK: Comparative assessment of the toxicology of vita min A and retinoids in man. Toxicology 57: 117–161, 1989. 67 Sato M, Lieber CS: Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats. J Nutr 11: 2015–2023, 1981. 68 Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS: Increase of ethanol meprobamate and phenobarbital metabolism after chronic ethanol administration in man and in rats. Am J Med 51: 346–351, 1971. 69 Joly, J-G, Ishii H, Teschke R, Hasumura T, Lieber CS: Effect of chronic ethanol feeding on the activities and submicrosomal distribution of reduced nicotinamide adenine dinucleotide phosphate (NADPH)- cytochrome P-450 reductase and the demethylases for aminopyrine and ethyl-morphine. Biochem Pharmacol 22: 1532–1535, 1973. 70 Leo MA, Lieber CS: New Pathway for retinol metabolism in liver microsomes. J Biol Chem 260: 5228–5231, 1985. 71 Felder MR, Burnett KG, Balak, KJ: Genetics, biochemistry, and developmental regulation of alcohol dehydrogenase in peromyscus and laboratory mice. Isozymes Cum Top Biol Med Res 9; 143–161, 1983. 72 Posch KC, Enright WJ, Napoli JL: Retinoic acid synthesis by cytosol from the alcohol dehydrogenase negative deermouse. Arch Biochem Biophys 274: 171–178, 1989. 73 Ditlow CC, Holmquist B, Morelock MM, Vallee BL: Physical and enzymatic properties of a class II alchol dehydrogenase isozyme of human liver: π-ADH. Biochemistry 23: 6363–6368, 1984. Citing Literature Volume15, Issue3June 1991Pages 560-564 ReferencesRelatedInformation