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Identification and characterization of a novel l-amino acid ligase from Photorhabdus luminescens subsp. laumondii TT01

2010; Elsevier BV; Volume: 110; Issue: 1 Linguagem: Inglês

10.1016/j.jbiosc.2009.12.004

1389-1723

Kuniki Kino, Atsushi Noguchi, Toshinobu Arai, Makoto Yagasaki,

Plant Pathogenic Bacteria Studies

l-Amino acid ligase catalyzes dipeptide synthesis from unprotected l-amino acids in an ATP-dependent manner. We recently identified a new member of l-amino acid ligase, the plu1440 protein, from Photorhabdus luminescens subsp. laumondii TT01 by in silico analysis. This protein was found to synthesize dipeptides containing l-asparagine at the N-terminus, which is a novel substrate specificity.