Liver Adaptation and Injury in Alcoholism
1973; Massachusetts Medical Society; Volume: 288; Issue: 7 Linguagem: Inglês
10.1056/nejm197302152880710
ISSN1533-4406
AutoresRalf Steinmetz, Christine Balko, Charles S. Lieber,
Tópico(s)Alcoholism and Thiamine Deficiency
ResumoHEPATIC changes are very common in alcoholics, and their development is determined both by the amount and by the duration of ethanol intake.1 The questions most frequently asked are whether these changes are truly caused by alcohol itself or merely by the associated malnutrition, and, if alcohol does have direct effects on the liver, whether they are all injurious, or whether some can be considered adaptive. Regarding the first question, a number of studies conducted over the last 10 years by me and my associates have shown that although nutritional factors are undoubtedly involved, alcohol itself has to be incriminated . . .
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