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CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4 H -3,1-Benzoxazines

2011; American Chemical Society; Volume: 77; Issue: 2 Linguagem: Inglês

10.1021/jo2020399

1520-6904

Bing Han, Xiu‐Long Yang, Chao Wang, Yong‐Wei Bai, Tai‐Chao Pan, Xin Chen, Wei Yu,

Phenothiazines and Benzothiazines Synthesis and Activities

The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.