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Constituents of the Leaves and Twigs of Ficus hispida

2002; Thieme Medical Publishers (Germany); Volume: 68; Issue: 2 Linguagem: Inglês

10.1055/s-2002-20257

1439-0221

Sergio R. Peraza‐Sánchez, Heebyung Chai, Young G. Shin, Thawatchai Santisuk, Vichai Reutrakul, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn,

Banana Cultivation and Research

A new norisoprenoid, ficustriol (1), and the known phenanthroindolizidine alkaloid O-methyltylophorinidine (2), were isolated from a CHCl3 extract of the leaves and twigs of Ficus hispida. O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods.