The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba
1996; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês
10.1016/0968-0896(95)00155-7
ISSN1464-3391
AutoresGeng‐Xian Zhao, Jin‐Feng Chao, Lu Zeng, Matthew J. Rieser, J. L. McLaughlin,
Tópico(s)Phytochemical compounds biological activities
ResumoA novel acetogenin, asiminocin (1), was isolated by activity-directed fractionation from the stem bark of the paw paw tree, Asimina triloba. By spectral and chemical methods, 1 was identified as (30S)-hydroxy-4-deoxyasimicin. The absolute configuration of 1, along with those of previously reported acetogenins asimin, asiminacin, bullatin, (30S)-bullanin, and (30R) bullanin, was determined by Mosher ester methodology. Compound 1 was highly inhibitory to three human solid tumor cell lines with over a billion times the potency of adriamycin.
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