Cytotoxic and Antitumor Constituents in Pericarps of Mallotus japonicus
1990; Thieme Medical Publishers (Germany); Volume: 56; Issue: 04 Linguagem: Inglês
10.1055/s-2006-960987
ISSN1439-0221
AutoresMunehisa Arisawa, Akio Fujita, Naokata Morita, Shunichi Koshimura,
Tópico(s)Natural Compound Pharmacology Studies
ResumoA variety of phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus were assessed for growth inhibiting activity against human larynx (HEp-2) and lung (PC-13) carcinoma cells as well as mouse B16 melanoma, leukemia P388, and L5178Y cells. Most of these derivatives were proved to be significantly cytotoxic in culture. One of them, 3-(3,3-di-methylallyl)-5-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzyl)-phloracetophenone (1) showed an excellent cytotoxicity against all target tumor cells and a marked prolongation of life-span in mice bearing L5178Y leukemia.
Referência(s)