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Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease

1992; Wiley; Volume: 43; Issue: 4 Linguagem: Inglês

10.1002/ajmg.1320430421

1096-8628

Elina Ikonen, Armi Salo, Mirja Somer, Hannu Somer, Leena Pääkkönen, Leena Peltonen,

Chromosomal and Genetic Variations

Abstract A 15‐year‐old boy with a terminal deletion of the short arm of chromosome 4 is described. The patient has a mild clinical phenotype that is incompatible with Wolf‐Hirschhorn syndrome. Careful neurological examination including CT scan did not show any signs of Huntington disease. The chromosomal breakpoint was analyzed by means of polymorphic DNA probes localized close to the tentative Huntington (HD) locus. The breakage has occurred between D4S43 and D4S90 loci and thus deletes part of the chromosomal candidate regions for the HD locus. © 1992 Wiley‐Liss, Inc.