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Salmonella Infection in Total Hip Replacement: Tests to Predict the Outcome of Antimicrobial Therapy

1990; Informa; Volume: 22; Issue: 5 Linguagem: Inglês

10.3109/00365549009027105

1651-1980

Andreas F. Widmer, V. Colombo, André Gächter, G Thiel, Werner Zimmerli,

Total Knee Arthroplasty Outcomes

We report a hematogenous implant infection with Salmonella dublin in a renal transplant patient with total hip replacement. A 16-month treatment with cotrimoxazole foiled, as evidenced by culture and electron microscopy, despite persisting low MIC after therapy. Data from a foreign body animal model and in vitro tests, which take into account the properties of adhering and stationary-phase bacteria, explain the failure of a long-term treatment with cotrimoxazole. The patient was subsequently cured by ciprofloxacin which was successful in these tests. No relapse was noted after a follow-up of 1 year.