Produção Nacional
Revisado por pares
Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog
1999; Elsevier BV; Volume: 64; Issue: 2 Linguagem: Inglês
10.1016/s0378-8741(98)00116-0
ISSN1872-7573
AutoresJ.C.T. Carvalho, Jayme Antônio Aboin Sertié, Marcos V.J Barbosa, Kensuly C.M Patrı́cio, Lucélia Rita Gaudino Caputo, S J Sarti, Luciano P Ferreira, Jairo Kenupp Bastos,
Tópico(s)Plant-Derived Bioactive Compounds
ResumoThe vegetal species Pterodon emarginatus Vog. (Leguminosae/Papilonaceae), popularly known in Brazil as 'sucupira branca', is widely used by domestic medicine as an anti-inflammatory. From these observations, the hexanic crude extract (HCE) of the fruits was obtained and submitted for assessment of its anti-inflammatory activity. For this purpose, the following tests were used: (1) Determination of ED50 and LD50; (2) Paw edema induced by carrageenin, dextran, histamine and nystatin; (3) Peritonitis caused by carrageenin and (4) Granuloma test. The ED50 (oral) in the edema induced by carrageenin was 500 mg/kg, and LD50 (oral) was 4.02 g/kg. In the edema caused by nystatin, there was a significant inhibition by 45% (P < 0.05 student's t-test) at the 6th hour following the treatment. In the granuloma test performed in animals treated with HCE, there was an inhibition of the granulomatous tissue formation by 22%. The migration of neutrophils towards the peritoneal cavity was inhibited in HCE treated animals by 43% (P < 0.05). However, in the edema caused by dextran and histamine, there was no significant response in HCE treated animals.
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