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A Ku Bridge over Broken DNA

2001; Elsevier BV; Volume: 9; Issue: 10 Linguagem: Inglês

10.1016/s0969-2126(01)00658-x

1878-4186

Jessica M. Jones, Martin Gellert, Wei Yang,

DNA and Nucleic Acid Chemistry

Abstract The Ku heterodimer is essential for the nonhomologous end-joining pathway of DNA double-strand break repair; it both protects the broken ends and recruits some of the many proteins required to complete repair. The recently determined structure of Ku provides insights into how it can both bind to the DNA ends and allow access by the other proteins required to rejoin them.