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Ni(II), Cu(II), and Zn(II) Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells

2008; American Chemical Society; Volume: 51; Issue: 20 Linguagem: Inglês

10.1021/jm8007807

1520-4804

Boris Cvek, Vesna Milacic, Jan Taraba, Q. Ping Dou,

Cancer, Lipids, and Metabolism

A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and tested in human breast cancer MDA-MB-231 cells. Zinc and copper complexes, but not nickel complex, were found to be more active against cellular 26S proteasome than against purified 20S proteasome core particle. One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid.