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Interaction of nicotine and its pharmaceutical derivatives with acrylamide/itaconic acid hydrogels

1997; Wiley; Volume: 66; Issue: 4 Linguagem: Inglês

10.1002/(sici)1097-4628(19971024)66

1097-4628

Erdener Karada, Dursun Saraydın, Olgun G�ven,

Thermodynamic properties of mixtures

Journal of Applied Polymer ScienceVolume 66, Issue 4 p. 733-739 Interaction of nicotine and its pharmaceutical derivatives with acrylamide/itaconic acid hydrogels Erdener Karadağ, Corresponding Author Erdener Karadağ Department of Chemistry, Cumhuriyet University, 58140 Sivas, TurkeyDepartment of Chemistry, Cumhuriyet University, 58140 Sivas, Turkey===Search for more papers by this authorDursun Saraydin, Dursun Saraydin Department of Chemistry, Cumhuriyet University, 58140 Sivas, TurkeySearch for more papers by this authorOlgun Güven, Olgun Güven Department of Chemistry, Hacettepe University, 06532 Beytepe/Ankara, TurkeySearch for more papers by this author Erdener Karadağ, Corresponding Author Erdener Karadağ Department of Chemistry, Cumhuriyet University, 58140 Sivas, TurkeyDepartment of Chemistry, Cumhuriyet University, 58140 Sivas, Turkey===Search for more papers by this authorDursun Saraydin, Dursun Saraydin Department of Chemistry, Cumhuriyet University, 58140 Sivas, TurkeySearch for more papers by this authorOlgun Güven, Olgun Güven Department of Chemistry, Hacettepe University, 06532 Beytepe/Ankara, TurkeySearch for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1097-4628(19971024)66:4 3.0.CO;2-SCitations: 16AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Acrylamide/itaconic acid hydrogels (AAm/IA) containing different amounts of itaconic acid prepared by irradiating with γ radiation were used in experiments on swelling, diffusion, and interactions of the pharmaceuticals nicotine, nicotinic acid, nicotinamide, and nikethamide. AAm/IA hydrogel containing 60 mg itaconic acid and irradiated at 4.65 kGy has been used for swelling and diffusion studies in water and aqueous solutions of the pharmaceuticals. For this hydrogel, swelling studies indicated that swelling increased with the following order: water > nicotine > nikethamide > nicotinamide > nicotinic acid. Diffusions of water and the pharmaceuticals within hydrogels were found to be non-Fickian in character. The uptake of the pharmaceuticals to AAm/IA hydrogels was studied by batch adsorption technique at 25°C. In the experiments of the adsorption, C-type adsorption in Giles's classification system was found. Some binding and thermodynamic parameters for AAm/IA hydrogel-pharmaceutical systems were calculated by using the Klotz method. The values of adsorption heat, free energy, and entropy of this system were found as negative values. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 733–739, 1997 Citing Literature Volume66, Issue424 October 1997Pages 733-739 RelatedInformation