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Clonidine in Heroin Withdrawal Syndrome: a controlled study in India

1988; Wiley; Volume: 83; Issue: 9 Linguagem: Inglês

10.1111/j.1360-0443.1988.tb00535.x

2056-5178

Aditya K. Gupta, Brajesh Kumar Jha,

Epilepsy research and treatment

Summary The efficacy of clonidine in controlling heroin withdrawal symptoms has been compared to that of a chlordiazepoxide and chlorpromazine combination in 120 male Indian patients in a single blind controlled design. Rhinorrhoea, nausea, vomitting, diarrhoea, confusion, disorientation and delirium were observed to occur significantly less often in patients receiving clonidine. Only 6.67%patients on clonidine developed severe hypotension. Clonidine was observed to be relatively safe and effective as a single drug for inpatients in the detoxification programme as compared to tranquillizers alone. The therapeutic effects and side effects observed were similar to those reported in European and American studies.