Genetic studies in Sjögren's syndrome and systemic lupus erythematosus
1989; Elsevier BV; Volume: 2; Issue: 4 Linguagem: Inglês
10.1016/0896-8411(89)90169-8
ISSN1095-9157
AutoresFrank C. Arnett, Wilma Β. Bias, John D. Reveille,
Tópico(s)Salivary Gland Disorders and Functions
ResumoHLA associations with Sjögren's syndrome (SS), previously defined by serologic HLA typing, are reviewed. Because the SS-A/Ro and SS-B/La autoantibody responses in SS and systemic lupus erythematosus (SLE) show even stronger correlations with HLA alleles, HLA-DR and DQ alleles were examined using restriction fragment length polymorphisms (RFLP) in white and black patients with SS and/or SS having anti-Ro and anti-La antibodies. The strongest associations across ethnic lines were with HLA-DR3, DQw2 and DQw1.2 (DQw6), especially the DQw1.2 (DQw6)/Dqw2 heterozygous state. HLA-DQw3 was relatively decreased. These data suggest that HLA-DQ is most likey responsible for these abnormal autoantibody responses. In addition, multiplex family studies of Ro antibodies demonstrates the requirement for both HLA and non-MHC effects.
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