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Endocrine Differences between the Wistar and Sprague-Dawley Laboratory Rat: Influence of Cold Adaptation

1983; Thieme Medical Publishers (Germany); Volume: 15; Issue: 10 Linguagem: Inglês

10.1055/s-2007-1018767

1439-4286

E Kuhn, K. Bellon, L. Huybrechts, Walter Heyns,

Birth, Development, and Health

Sprague-Dawley (SD) rats kept at room temperature do have a higher growth rate and food conversion compared to Wistar rats. Mean hormone level in blood samples collected every four hours during a 24 hour period do differ between both strain of rats. So, the mean circulating levels of T3, T4 and corticosterone are significantly lower, whereas prolactin concentrations are higher in SD-rats. Following acute cold exposure comparable increases in plasma T3, and T4 are seen in both strains after 3-5 hours. Prolactin plasma concentrations are decreased after 5 and 9 hours but only in SD-rats, whereas they remain unchanged in Wistars.