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Meta-Analysis of Infectious Agents and Depression

2014; Nature Portfolio; Volume: 4; Issue: 1 Linguagem: Inglês

10.1038/srep04530

2045-2322

Xiao Wang, Liang Zhang, Lei Yang, Xia Liu, Xinyu Zhou, Yiyun Liu, Mingju Wang, Yang Liu, Lujun Zhang, Songhua Fan, Peng Xie,

Gut microbiota and health

Depression is a debilitating psychiatric disorder and a growing global public health issue. However, the relationships between microbial infections and depression remains uncertain. A computerized literature search of Medline, ISI Web of Knowledge, PsycINFO and the Cochrane Library was conducted up to May 2013 and 6362 studies were initially identified for screening. Case-control studies detected biomarker of microorganism were included. Based on inclusion and exclusion criteria, 28 studies were finally included to compare the detection of 16 infectious agents in unipolar depressed patients and healthy controls with a positive incident being defined as a positive biochemical marker of microbial infection. A customized form was used for data extraction. Pooled analysis revealed that the majority of the 16 infectious agents were not significantly associated with depression. However, there were statistically significant associations between depression and infection with Borna disease virus, herpes simplex virus-1, varicella zoster virus, Epstein-Barr virus and Chlamydophila trachomatis.