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Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia

2015; Elsevier BV; Volume: 125; Issue: 23 Linguagem: Inglês

10.1182/blood-2015-01-620781

1528-0020

Dorothée Selimoglu‐Buet, Orianne Wagner‐Ballon, Véronique Saada, Valérie Bardet, Raphaël Itzykson, Laura Bencheikh, Margot Morabito, Elisabeth Met, Camille Debord, Emmanuel Benayoun, Anne-Marie Nloga, Pierre Fenaux, Thorsten Braun, Christophe Willekens, Bruno Quesnel, Lionel Adès, Michaëla Fontenay, Philippe Rameau, Nathalie Droin, Serge Koscielny, Éric Solary,

Chemokine receptors and signaling

Key Points An increase in the classical monocyte subset to >94% of total monocytes discriminates CMML from other monocytoses with high specificity. This characteristic increase in classical monocytes disappears in CMML patients who respond to hypomethylating agents.