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Neonatal Lupus Erythematosus Related to Maternal Leukocytoclastic Vasculitis

1997; Wiley; Volume: 14; Issue: 3 Linguagem: Inglês

10.1111/j.1525-1470.1997.tb00243.x

1525-1470

Leopoldo Borrego, Julio César Rodríguez, Elena Soler, A Candelaria Jiménez, Buenaventura Hernández,

Cell Adhesion Molecules Research

Neonatal lupus erythematosus (NLE) is an autoimmune disease whose major findings are skin lesions and congenital heart block. Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases. Mothers of babies with NLE may be asymptomatic initially or may have Sjögren syndrome, lupus erythematosus, overlap syndrome or, uncommonly, leukocytoclastic vasculitis. When evaluating a young woman with a cutaneous leucocytoclastic vasculitis, dermatologists should be aware of the possible presence of antibodies related to NLE. If any patient suffering a disorder related to NLE becomes pregnant, testing for autoantibodies and close obstetric prenatal care with fetal echocardiogram is necessary. In cases of fetal bradycardia, treatment with dexamethasone or betamethasone should be considered, as these drugs are accessible to the fetal circulation.