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Primary multicentric anaplastic pleomorphic xanthoastrocytoma with atypical features

2013; Elsevier BV; Volume: 20; Issue: 11 Linguagem: Inglês

10.1016/j.jocn.2012.09.046

1532-2653

Nicola Montano, Fabio Papacci, Beatrice Cioni, Simona Gaudino, Giuseppe Maria Della Pepa, Giulio Conforti, Rina Di Bonaventura, Mariangela Novello, Libero Lauriola, Mario Meglio,

Ubiquitin and proteasome pathways

Pleomorphic xanthoastrocytoma (PXA) is a rare tumor with good prognosis after surgery. Few cases of anaplastic PXA (either de novo or secondary to transformation of a recurrent low grade PXA) have been reported. Moreover, primary anaplastic PXA with dissemination at diagnosis has been described only in two patients, to our knowledge. We report the first case of primary multicentric anaplastic PXA and discuss its atypical features and the pertinent literature.