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Effect of citral, eugenol, nerolidol and α-terpineol on the ultrastructural changes of Trichophyton mentagrophytes

2009; Elsevier BV; Volume: 80; Issue: 5 Linguagem: Inglês

10.1016/j.fitote.2009.03.007

1873-6971

Mi Jin Park, Ki‐Seob Gwak, Inho Yang, K.W. Kim, Eui‐Bae Jeung, Jin-Sheng Chang, Indae Choi,

Phytochemistry and Biological Activities

The antifungal effects of citral, eugenol, nerolidol and α-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of α-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and α-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption.