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Gly145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus

1992; Elsevier BV; Volume: 184; Issue: 3 Linguagem: Inglês

10.1016/s0006-291x(05)80003-8

1090-2104

Hidehiko Fujii, Kousuke Moriyama, N Sakamoto, Toshifumi Kondo, Kiyomi Yasuda, Y. Hiraizumi, M Yamazaki, Y. Sakaki, K. Okochi, Etsuro Nakajima,

Blood groups and transfusion

A Japanese child born to an HBeAg-positive carrier mother received antiHBs immunoglobulins and a plasma-derived HBs vaccine with a poor antiHBs-antibody response. The child, who is now 3 years old, is presently suffering from chronic hepatitis with unusual serological findings that are positive for HBeAg, anti-HBs and HBeAg, since being infected with a measles virus at 12 months of age. The nucleotide sequences of the S region of HBV DNA obtained from the patient, the mother and an HBeAg-positive brother were completely identical except for one nucleotide at position 587 (mother and brother: guanosine, patient: adenosine), giving an amino acid change: Gly -> Arg at position 145 of the major HBs protein.