Portal de Periódicos da CAPES

Is multiple pregnancy an unavoidable complication of ovulation induction? The case for pulsatile GnRH

1996; Elsevier BV; Volume: 65; Linguagem: Inglês

10.1016/0301-2115(96)02414-1

1872-7654

Marco Filicori, Graçiela Estela Cognigni, R. Arnone, Ilma Floriana Carbone, Angela Falbo, C. Tabarelli, C. Pari, Walter Ciampaglia, Paolo Casadio, Daniela Spettoli, R. Pecorari,

Reproductive Biology and Fertility

Ovarian hyperstimulation (OHS) and multiple pregnancy are dreaded complications of ovulation induction. The use of pulsatile GnRH permits to prevent the occurrence of OHS and results in few multiple pregnancies. Low-dose GnRH administration, avoidance of preovulatory hCG, patient selection, and the use of GnRH agonist pituitary desensitization in selected patients permits to limit multiple conceptions to a level comparable with the occurrence of this complication in normal unstimulated women.