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Nevus Spilus (Speckled Lentiginous Nevus) Associated with a Nodular Neurotized Nevus

1997; Lippincott Williams & Wilkins; Volume: 19; Issue: 3 Linguagem: Inglês

10.1097/00000372-199706000-00020

1533-0311

Sang Min Hwang, Eung Ho Choi, Won Soo Lee, Soo Im Choi, Sung Ku Ahn,

Cutaneous Melanoma Detection and Management

We report a case of nevus spilus with neurotized nevus studied by immunohistochemical methods using S-100, leu-7, glial fibrillary acid protein (GFAP), and myelin basic protein (MBP). Histologic findings of the speckled lesion showed irregular rete ridge elongation, increased epidermal melanocytes and melanin in the epidermis, and scattered nevus cell nests in the upper dermis, but showed neurotized nevus in the deep dermis, which has many features of neurofibroma. Diffuse expression of S-100 protein and MBP, focal staining with GFAP, and lack of staining with leu-7 were observed. Leu-7, positive only in neurofibromas and not in neurotized nevus, appears to be the more pertinent method for distinguishing neurotized nevus from neurofibroma.