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BIBTEX RIS

Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae)

2010; Brazilian Chemical Society; Volume: 33; Issue: 10 Linguagem: Inglês

10.1590/s0100-40422010001000006

ISSN

1678-7064

Autores

Geraldo Humberto Silva, Camila Martins de Oliveira, Helder Lopes Teles, Vanderlan da Silva Bolzani, Ângela R. Araújo, Ludwig H. Pfenning, Maria Cláudia Marx Young, Claudio M. Costa‐Neto, Renato Haddad, Marcos N. Eberlin,

Tópico(s)

Phytochemical compounds biological activities

Resumo

AN ENDOPHYTIC FUNGUS FROM Piper aduncum.A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6).The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity.The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA.The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.

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