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Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide

2012; Multidisciplinary Digital Publishing Institute; Volume: 17; Issue: 5 Linguagem: Inglês

10.3390/molecules17055757

1433-1373

Aline Augusti Boligon, Michele Rorato Sagrillo, Luiz Filipe Machado, Olmiro De Souza Filho, Michel Mansur Machado, Ivana Beatrice Mânica da Cruz, Margareth Linde Athayde,

Morinda citrifolia extract uses

Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and ageing, possibly by preventing initial DNA damage. Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H2O2 in human lymphocytes by analyzing cellular growth rate, cell viability, mitotic index and chromosomal instability. We found a differential response among the compounds tested, with the ethyl acetate fraction being more effective than the crude extract, a difference perhaps related to the presence of the antioxidants identified and quantified by HPLC/DAD. In general, quercetin, isoquercitrin and rutin recovered the mitotic index and chromosomal instability more than quercitrin after treatment with hydrogen peroxide.