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Effect of liver damage caused by carbon tetrachloride on the secretion of bile salts and lipids into bile of sheep

1971; Elsevier BV; Volume: 81; Issue: 3 Linguagem: Inglês

10.1016/0021-9975(71)90029-6

1532-3129

I. W. Caple, T Heath,

Drug-Induced Hepatotoxicity and Protection

The rates of secretion of bile, bile salts and total biliary fatty acids decreased within an hour after carbon tetrachloride was injected into the portal vein of conscious sheep and by the fifth hour were less than one-half the control values. Other experiments were performed on anaesthetised sheep at the time of maximum liver damage, 24 hr. after carbon tetrachloride was given by stomach tube. The carbon tetrachloride did not markedly affect the choleretic action of secretin, which is believed to act on the bile ducts and ductules. However, it did cause a significant depression in the ability of the hepatocytes to transport bile salts and lipids into bile during infusion of taurocholate into the portal vein. These results indicate that administration of carbon tetrachloride to sheep may be followed by a decrease in the rate of delivery into the intestine of lipids and bile salts, materials that are esential for the normal absorption of dietary fat.