Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe
2010; Elsevier BV; Volume: 3; Issue: 3 Linguagem: Inglês
10.1016/j.phytol.2010.04.003
ISSN1876-7486
AutoresLaurence Jones, Jacqueline Hollinshead, George W. J. Fleet, Amber L. Thompson, D.J. Watkin, Zoltán A. Gál, Sarah F. Jenkinson, Atsushi Kato, Robert J. Nash,
Tópico(s)Synthesis and Biological Activity
ResumoThe Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report the isolation of the novel polyhydroxylated pyrrolizidine alkaloid, 1-epialexine, from the leaves and stems of C. australe. 1-Epialexine is a weak inhibitor of β-mannosidase from Cellullomonas fimi.
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