Reversed end-diastolic umbilical flow in a first-trimester fetus with congenital heart disease
1998; Wiley; Volume: 18; Issue: 10 Linguagem: Inglês
10.1002/(sici)1097-0223(1998100)18
ISSN1097-0223
AutoresA. Borrell, Dolors Costa, Josep M. Martínez, Magí Farré, Montse Palacio, Carlos Mortera, Albert Fortuny,
Tópico(s)Congenital Diaphragmatic Hernia Studies
ResumoReversed end-diastolic umbilical artery velocities and a reduced chorionic sac were first seen at 10 weeks in a pregnancy subsequently showing a normal male karyotype on chorionic villi. Four weeks later Doppler studies demonstrated normal umbilical artery waveforms. At 20 weeks, ultrasound examination of the fetus revealed a mild pericardic effusion, hypoplastic righ heart with hypertrophic myocardium and a single umbilical artery, suggesting pulmonary atresia. After neonatal death, pathological studies confirmed pulmonary atresia. This case suggests that reversed end-diastolic umbilical flow in the first trimester may identify a subgroup of fetuses with a lethal abnormality (heart defect, severe intra-uterine retardation, aneuploidy or others).
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