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Studies of splenomegaly in rodent malaria I. The course of splenomegaly in mice infected with Eperythrozoon coccoides, Plasmodium berghei yoelii and the two infections combined

1969; Oxford University Press; Volume: 63; Issue: 1 Linguagem: Inglês

10.1016/0035-9203(69)90067-4

1878-3503

Pravan Suntharasamai, Philip D. Marsden,

Vector-borne infectious diseases

The course of splenomegaly in E. coccoides or P. b. yoelii infection or both was studied in 344 TO mice. Spleen size (% spleen weight to body weight) and infection rate were recorded at intervals of 4 days for 32 days after infection. In E. coccoides infection the spleens were enlarged from D4 to D8 and were twice as large as the controls, P. b. yoelii infection occurred from D8 to D28 and the maximum average was 6 times that of the control. No significant cumulative effect on spleen size was obtained with mixed infections.