Deficit of Brain and Skeletal Muscle Bioenergetics and Low Brain Magnesium in Juvenile Migraine: An in Vivo 31P Magnetic Resonance Spectroscopy Interictal Study
1997; Springer Nature; Volume: 42; Issue: 6 Linguagem: Inglês
10.1203/00006450-199712000-00024
ISSN1530-0447
AutoresRaffaele Lodi, Pasquale Montagna, Stefano Soriani, Stefano Iotti, Claudia Arnaldi, Pietro Cortelli, Giulia Pierangeli, Alberto Patuelli, P. Zaniol, Bruno Barbiroli,
Tópico(s)Traumatic Brain Injury and Neurovascular Disturbances
ResumoWe used phosphorus magnetic resonance spectroscopy (31P MRS) to investigate in vivo the brain and skeletal muscle energy metabolism of 15 children with migraine with aura in interictal periods. Brain 31P MRS disclosed low phosphocreatine and high inorganic phosphate contents, and high intracellular pH in all patients. Calculated [ADP] and the relative rate of mitochondrial oxidation were higher in the brain of patients than in control subjects, whereas the phosphorylation potential was lower. Brain intracellular free Mg2+ concentration was reduced by 25% in patients. Abnormal skeletal muscle mitochondrial respiration was also disclosed in 7 of 15 patients as shown by the slow rate of phosphocreatine postexercise recovery. The multisystem bioenergetic failure found in patients with juvenile migraine is comparable to that found in adults with different types of migraine.
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