PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate
2001; Elsevier BV; Volume: 26; Issue: 1 Linguagem: Inglês
10.1016/s0968-0004(00)01699-6
ISSN1362-4326
AutoresDavid A. Okar, Alex J. Lange, Ànna Manzano, Àurea Navarro‐Sabaté, L. Riera, Ramón Bartrons,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoFructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.
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