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Synthesis, characterization and antimicrobial evaluation of novel halopyrazole derivatives

2011; Elsevier BV; Volume: 17; Issue: 2 Linguagem: Inglês

10.1016/j.jscs.2011.03.016

2212-4640

Zeba N. Siddiqui, Farheen Farooq, T. N. Mohammed Musthafa, Anis Ahmad, Asad U. Khan,

Essential Oils and Antimicrobial Activity

Two novel halopyrazole derivatives (3, 5) were synthesized from 5-chloro-3-methyl-1-phenylpyrazole-4-carboxaldehyde (1) using appropriate synthetic routes. Newly synthesized compounds were characterized using elemental analysis, spectral data (IR, 1H NMR, 13C NMR and mass spectrometry) and were evaluated for their in vitro antimicrobial activity. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were determined for the test compounds as well as for reference standards. The investigation of antimicrobial screening revealed that compounds (3, 5) showed good antibacterial and antifungal activities, respectively.