Portal de Periódicos da CAPES

Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple-quantum-filtered signals

1999; Wiley; Volume: 9; Issue: 4 Linguagem: Inglês

10.1002/(sici)1522-2586(199904)9

1522-2586

Joseph A. Kmiecik, Carl D. Gregory, Zhi‐Pei Liang, Paul C. Lauterbur, M. Joan Dawson,

Atomic and Subatomic Physics Research

Journal of Magnetic Resonance ImagingVolume 9, Issue 4 p. 539-543 Original ResearchFree Access Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple-quantum-filtered signals† Joseph A. Kmiecik MD, PhD, Joseph A. Kmiecik MD, PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorCarl D. Gregory PhD, Carl D. Gregory PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorZhi-Pei Liang PhD, Zhi-Pei Liang PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorPaul C. Lauterbur PhD, Paul C. Lauterbur PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorM. Joan Dawson PhD, Corresponding Author M. Joan Dawson PhD mjd@bmrl.med.uiuc.edu Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.524 Burrill Hall, 407 S. Goodwin Ave., Urbana, IL 61801.Search for more papers by this author Joseph A. Kmiecik MD, PhD, Joseph A. Kmiecik MD, PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorCarl D. Gregory PhD, Carl D. Gregory PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorZhi-Pei Liang PhD, Zhi-Pei Liang PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorPaul C. Lauterbur PhD, Paul C. Lauterbur PhD Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.Search for more papers by this authorM. Joan Dawson PhD, Corresponding Author M. Joan Dawson PhD mjd@bmrl.med.uiuc.edu Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana Illinois 61801.524 Burrill Hall, 407 S. Goodwin Ave., Urbana, IL 61801.Search for more papers by this author First published: 28 April 1999 https://doi.org/10.1002/(SICI)1522-2586(199904)9:4 3.0.CO;2-ACitations: 9 † Presented in part at the 5th Annual ISMRM Meeting, Vancouver, 1997. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Quantitative magnetic resonance imaging of lactate using a zero-quantum/double-quantum filter and generalized spectral localization by imaging (GSLIM) was applied to a model of unilateral stroke in gerbil brain. GSLIM lactate images at 4T clearly reveal elevated concentrations of lactate in the ischemic compared with the normal hemisphere 100–175 minutes after unilateral carotid ligation. These results indicate that the technique is capable of studies of brain infarcts, and that application to human ischemic pathology in brain and other tissues may be possible.J. Magn. Reson. Imaging 1999;9:539–543. © 1999 Wiley-Liss, Inc. REFERENCES 1 Graham GD, Kalvach P, Blamire AM, Brass LM, Fayad PB, Prichard J. W. Clinical correlates of proton magnetic resonance spectroscopy findings after acute cerebral infarction. Stroke 1995; 26: 225– 229. Medline 2 Federico F, Simone IL, Conte C, et al. Prognostic significance of metabolic changes detected by proton magnetic resonance spectroscopy in ischaemic stroke. J Neurol 1996; 243: 241– 247. Medline 3 Gillard JH, Barker PB, van Zijl PC, Bryan RN, Oppenheimer SM. Proton MR spectroscopy in acute middle cerebral artery stroke. AJNR 1996; 17: 873– 886. Medline 4 Hentschel D, Ladebeck R, Witting R, Schuler P, Schuierer G. Quantitative in vivo 1H-spectroscopy of healthy and tumorous human brain tissue at 4 Tesla. Appl Magn Reson 1990; 1: 379– 412. 5 Yue NC. Advances in brain tumor imaging. Curr Opin Neurol 1993; 6: 831– 840. Medline 6 Sijens PE, Knopp MV, Brunetti A, et al. 1H MR spectroscopy in patients with metastatic tumors: a multicenter study. Magn Reson Med 1995; 33: 818– 826. Medline 7 Stubbs M, Veech RL, Griffiths JR. Tumor metabolism: the lessons of magnetic resonance spectroscopy. Adv Enzyme Regul 1995; 35: 101– 115. Medline 8 Shulman RG, Blamire AM, Rothman DL, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proc Natl Acad Sci USA 1993; 90: 3127– 3133. Medline 9 Hetherington HP, Hamm JR, Pan JW, Rothman DL, Shulman RG. A fully localized 1H homonuclear editing sequence to observe lactate in human skeletal muscle after exercise. J Magn Reson 1989; 82: 86– 96. 10 Hu X, Levin DN, Lauterbur PC, Spraggins T. SLIM: spectral localization by imaging. Magn Reson Med 1988; 8: 314– 322. Medline 11 Liang Z-P, Lauterbur PC. A theoretical analysis of the SLIM technique. J Magn Reson B 1993; 102: 54– 60. 12 Liang Z-P, Lauterbur PC. A generalized series approach to MR spectroscopic imaging. IEEE Trans Med Imaging 1991; 10: 132– 137. 13 Kmiecik JA, Gregory CD, Liang Z-P, Hrad DE, Lauterbur PC, Dawson M. Quantitative lactate-specific MR imaging and 1H spectroscopy of skeletal muscle and macroscopic and microscopic resolutions using a zero-quantum/double-quantum coherence filter and SLIM/GSLIM localization. Magn Reson Med 1997; 37: 840– 850. Medline 14 Mrsulja BB, Lust WD, Mrsulja BJ, Passonneau JV, Klatzo I. Post-ischemic changes in certain metabolites following prolonged ischemia in the gerbil cerebral cortex. J Neurochem 1976; 26: 1099– 1103. 15 Thulborn KR, du Boulay GH, Duchen LW, Radda G. A 31P nuclear magnetic resonance in vivo study of cerebral ischaemia in the gerbil. J Cereb Blood Flow Metab 1982; 2: 299– 306. Medline 16 Norris DG, Niendorf T, Hoehn-Berlage M, et al. Incidence of apparent restricted diffusion in three different models of cerebral infarction. Magn Reson Imaging 1994; 12: 1175– 1182. Medline 17 Middleton DA, Hockings PD, Glen S, et al. Image directed proton spectroscopy of gerbil brain at 7 tesla. NMR Biomed 1995; 8: 118– 126. Medline 18 Reese T, Norris DG, Leibfritz D. A fast method for in vivo lactate imaging. NMR Biomed 1995; 8: 225– 231. Medline 19 Trimble LA, Shen JF, Wilman AH, Allen PS. Lactate editing by means of selective-pulse filtering of both zero- and double-quantum coherence signals. J Magn Reson 1990; 86: 191– 198. 20 Dreher W, Kuhn B, Gyngell ML, et al. Temporal and regional changes during focal ischemia in rat brain studied by proton spectroscopic imaging and quantitative diffusion NMR imaging. Magn Reson Med 1998; 39: 878– 888. Medline 21 Xu S, Yang Y, Gregory CD, Vary JC, Liang Z-P, Dawson MJ. Biochemical heterogeneity in hysterectomized uterus measured by 31P NMR using SLIM localization. Magn Reson Med 1997; 37: 736– 743. Medline 22 Yang Y, Xu S, Dawson MJ, Lauterbur PC. Diffusion measurement in phantoms and tissues using SLIM localization. J Magn Reson 1997; 129: 161– 164. Medline 23 Fletcher ES, Syed I, Pae S, et al. An in vivo study of brain biochemistry in differentially reared rats using 31P spectral localization by imaging (SLIM). In: Abstracts of the Eleventh Annual Meeting of the Society of Magnetic Resonance in Medicine, Berlin, Germany, 1992. p 2124. 24 Gregory CD, Yang Y, Shimony J, et al. Toward quantitative three-dimensional analysis of functional regions of the human brain using SLIM and GSLIM. In: Abstracts of the Eleventh Annual Meeting of the Society of Magnetic Resonance in Medicine, Berlin, Germany, 1992. p 3830. 25 Löffler R, Sauter R, Kolem H, Haase A, vonKienlin M. Localized spectroscopy from anatomically matched compartments: improved sensitivity and localization for cardiac 31P MRS in humans. J Magn Reson 1998; 134: 287– 299. Medline 26 Kmiecik JA. Quantitative lactate-specific magnetic resonance imaging and 1H spectroscopy of muscle and brain. PhD thesis, University of Illinois at Urbana-Champaign, 1996. Citing Literature Volume9, Issue4April 1999Pages 539-543 ReferencesRelatedInformation