Produção Nacional
Revisado por pares
Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidamides derivatives
2011; Brazilian Chemical Society; Volume: 22; Issue: 2 Linguagem: Inglês
10.1590/s0103-50532011000200022
ISSN1678-4790
AutoresMaurício Silva dos Santos, Adriana O. Gomes, Alice M. R. Bernardino, Marcos C. de Souza, Misbahul Ain Khan, Monique Araújo de Brito, Helena Carla Castro, Paula Alvarez Abreu, Carlos Rangel Rodrigues, Rosa M. M. de Léo, Leonor L. Leon, Marilene M. Canto‐Cavalheiro,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoChemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4-carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the compounds of the series. Compound 2 showed an activity profile that can be improved through medicinal chemistry strategies.
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