Effect of Long-Term Administration of Berberine on Scopolamine Induced Amnesia in Rats.
1997; Japanese Pharmacological Society; Volume: 74; Issue: 3 Linguagem: Inglês
10.1254/jjp.74.261
ISSN1347-3506
AutoresWeng-Huang Peng, Ming‐Tsuen Hsieh, Chi‐Rei Wu,
Tópico(s)Berberine and alkaloids research
Resumo—The effect of berberine (BER) on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that BER at the doses of 0.1 and 0.5 g/kg after 7-day or 14-day administration significantly improved SCOP-induced amnesia. The anti-amnesic effect of BER after 14-day administration on the SCOP-induced amnesia was significantly augmented by physostigmine or neostigmine, and completely reversed by scopolamine N-methylbromide. These results suggest that the antiamnesic effect of BER after 14-day administration may be related to the increase in the peripheral and central cholinergic neuronal system activity.
Referência(s)