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C-reactive Protein and Atrial Fibrillation Is inflammation a consequence or a cause of atrial fibrillation?

2004; Japanese Heart Journal Assoc; Volume: 45; Issue: 3 Linguagem: Inglês

10.1536/jhj.45.441

1573-8612

Naoyuki Sata, Naokazu Hamada, Takashi Horinouchi, Shigeru Amitani, Takuya Yamashita, Yukinori Moriyama, Kenkichi Miyahara,

Acute Myocardial Infarction Research

To clarify whether inflammation is a cause or consequence of atrial fibrillation (AF), we measured high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) before and after pharmacological cardioversion in 15 patients with paroxysmal AF. Levels of hs-CRP, IL-6, and TNF-alpha after cardioversion were significantly higher than those in controls (P < 0.05). Furthermore, the levels of these indices did not differ significantly even at 24 hours and 2 weeks after cardioversion. These results suggest that inflammation is a causative agent of paroxymal AF.