Effect of fasting on free and esterified carnitine levels in human serum and urine: Correlation with serum levels of free fatty acids and β-hydroxybutyrate
1978; Elsevier BV; Volume: 27; Issue: 5 Linguagem: Inglês
10.1016/0026-0495(78)90022-7
ISSN1532-8600
AutoresJiří Fröhlich, David Seccombe, Peter Hahn, Peter Dodek, I. Hynie,
Tópico(s)Metabolomics and Mass Spectrometry Studies
ResumoSerum levels of free L-carnitine, acylcarnitines, creatinine, β-hydroxybutyrate, free fatty acids, cholesterol, triglycerides, and glucose were determined in healthy volunteers during a 24–36-hr fast. The effect of oral administration of free L-carnitine (1 g/person) on these parameters was studied. Urinary excretion of carnitine and creatinine was monitored throughout. Serum and urine levels of free carnitine and its renal clearance decreased during the fast. However, the serum concentration and urinary excretion of acylcarnitines increased during the same interval. Following the ingestion of free L-carnitine, both serum and urinary levels of free L-carnitine rose. Within 6 hr of ingestion, 10% of the administered dose could be accounted for by urinary excretion. No significant effect on the other serum constituents under study was seen following the oral L-carnitine dose. A significant negative correlation was found between serum levels of free L-carnitine and β-hydroxybutyrate and free fatty acids (r = −0.567, p < 0.001 and r = −0.607, p < 0.001, respectively) during the fast.
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