Prognostic Significance of Invasion Depth in Oral Tongue Squamous Cell Carcinoma
2012; Karger Publishers; Volume: 74; Issue: 5 Linguagem: Inglês
10.1159/000343796
ISSN1423-0275
AutoresWinson Jianhong Tan, Claramae Shulyn Chia, Hiang Khoon Tan, Khee‐Chee Soo, N. Gopalakrishna Iyer,
Tópico(s)Cholangiocarcinoma and Gallbladder Cancer Studies
ResumoStaging for tongue carcinoma does not consider its depth of invasion. We aim to determine the prognostic significance of invasion depth in tongue cancer.Retrospective review of patients with tongue carcinoma who underwent curative surgery between 2002 and 2005; 67 patients were analyzed. Tumors were divided into 2 groups: group A = invasion depth <4 mm; group B = invasion depth ≥4 mm. Recurrence and survival rates were calculated for each group and compared.The local recurrence rate in group B was significantly higher (10 vs. 29.7%, p = 0.048). Group A patients had a superior 5-year overall survival (68.8 vs. 41.6%, p = 0.012), disease-specific survival (67.1 vs. 41.1%, p = 0.026) and local recurrence-free survival (89.5 vs. 65.4%, p = 0.035). Five-year regional recurrence, locoregional recurrence and distant recurrence-free survival rates were not significantly different between the 2 groups (p = 0.390, p = 0.173 and p = 0.207). The impact of invasion depth on survival was maintained on multivariate analysis (p = 0.031).Invasion depth is an important prognostic indicator in tongue cancer.
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