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Clinical Trial of Inhaled Ergotamine Tartrate in Migraine

1964; BMJ; Volume: 1; Issue: 5377 Linguagem: Inglês

10.1136/bmj.1.5377.221

0959-8138

J. Crooks, Shine Stephen, W. Brass,

Psychedelics and Drug Studies

Periodic Migrainous Neuralgia-Balla and Walton MEBITALJOSHRNAL (921 Ekbom (1947) using " gynergen "1 reported results similar to our own.It has been our impression that gastro-intestinal side-effects were less marked with migril than with other preparations, but we have no statistically valid evidence to support this view.We are unable to throw any light on the aetiology of this condition.We see no reason why it should be attributed to histamine allergy and it is also difficult to relate it to migraine.In our cases a family history of migraine was rarely obtained, and this would be unexpected if this condition was indeed a variant of the migraine syndrome in which a positive family history is the rule rather than the exception.The age and sex distribution is also somewhat different from that of migraine, many of our patients having had their first symptoms in their forties.Though these are only two facets of the clinical picture, they may be of possible significance in distinguishing this syndrome from migraine. SummaryTwenty-eight cases of periodic migrainous neuralgia are reviewed.The cermical picture is described.The average time which elapsed between the onset of symptoms and accurate I Known in Great Britain as " femergen."diagnosis was 6.5 years.Our experiences of treatment using prophylactic migril in 20 patients are discussed.In 14 the response was satisfactory and in six relief was only slight.Two of these patients showed further improvement on prophylactic ergotamine injections.Three patients who failed to respond to oral ergotamine or relapsed responded to methyser- gide.A plea is made for early diagnosis in this eminently treatable condition.We are grateful to Dr. Henry Miller for allowing us to review a number of patients who were under his care.