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Biosynthesis of Hyperforin in Hypericum p erforatum

2002; American Chemical Society; Volume: 45; Issue: 21 Linguagem: Inglês

10.1021/jm0209782

1520-4804

Petra Adam, D. Arigoni, Adelbert Bacher, Wolfgang Eisenreich,

Biological Activity of Diterpenoids and Biflavonoids

Cut sprouts of Hypericum perforatum were proffered solutions containing [1-13C]glucose or [U-13C6]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties, which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway. The phloroglucinol moiety is generated via a polyketide type mechanism.