Protein β-turn mimetics I. Design, synthesis, and evaluation in model cyclic peptides.
1993; Elsevier BV; Volume: 49; Issue: 17 Linguagem: Inglês
10.1016/s0040-4020(01)90217-0
ISSN1464-5416
AutoresWilliam C. Ripka, George V. De Lucca, A. Bach, Richard S. Pottorf, Jeffrey M. Blaney,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoThe benzodiazepine (BZD) peptidomimetic I has been substituted for the naturally occurring four amino acid beta-turn in cyclo-(Gly-Pro-dPhe-dAla)2 and shown by NMR structural analysis to retain the double beta turn conformation in the resulting cyclic octapeptide, cyclo-(Gly-Pro-dPhe-dAla-BZD). This supports the proposal that the benzodiazepine scaffold is a useful beta-turn mimetic that preserved both the geometry of the turn and the positioning of the sidechains.
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