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AN AUTOPSY CASE OF VISCERAL HERPES SIMPLEX

1967; Wiley; Volume: 17; Issue: 2 Linguagem: Inglês

10.1111/j.1440-1827.1967.tb03162.x

1440-1827

Katsuji Nakata, Masuyo Nakai, Hiroki Hamawaki,

Hepatitis Viruses Studies and Epidemiology

Autopsy findings of visceral herpes simplex in a newborn infant and electronmicroscopic findings of both the liver cell and herpes simplex' virus are described. Severe hemorrhagic necrosis with intranuclear inclusion bodies and giant cell formation of liver cell, known to be characteristic to visceral herpes simplex, was found. Various developing stages of herpes simplex virus were observed in the liver cells by means of electronmicroscopy. Two types of intranuclear inclusion bodies were distinguished. One was a granular inclusion body which composed of various numbers of virus particles, and the other, Cowdry type A inclusion which did or did not contain virus particles. It was also shown that intranuclear aggregates, presumably of nonspecific protein, were responsible for the granular appearance of the inclusion body, and that the Cowdry type A inclusion body was formed by fusion of these aggregates. Several evidences suggested placental infection in the present case.