Secondary T‐acute lymphoblastic leukaemia mimicking blast crisis in chronic myeloid leukaemia
1999; Wiley; Volume: 106; Issue: 1 Linguagem: Inglês
10.1046/j.1365-2141.1999.01476.x
ISSN1365-2141
AutoresDawson, Slater, Hagemeijer, Langerak, Willemze, Kluin‐Nelemans,
Tópico(s)Chronic Lymphocytic Leukemia Research
ResumoA 34‐year‐old man with chronic myeloid leukaemia (CML) firstly developed a lymphoid blast crisis of B‐cell type. After a second chronic phase which lasted for > 4 years with maintenance chemotherapy of hydroxyurea, 6‐mercaptopurine and methotrexate, he developed a T‐cell acute lymphoblastic leukaemia of TcR‐γδ + type. Cytogenetic analysis revealed disappearance of the t(9;22) translocation and appearance of new abnormalities consistent with the diagnosis secondary acute leukaemia. To our knowledge, secondary leukaemia in CML has not previously been reported.
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