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A new synthesis of α,β-unsaturated ketones. Allylic alkylation of 1-isocyano-1-tosylalkenes

1984; Elsevier BV; Volume: 25; Issue: 24 Linguagem: Inglês

10.1016/s0040-4039(01)81237-5

1873-3581

J. MOSKAL, A. M. VAN LEUSEN,

Fluorine in Organic Chemistry

Ketone (1) are homologated to enones 2 by alkylating (introduction of R3) the condensation products 4 (derived from 1 and tosylmethyl isocyanide), followed by acid catalyzed hydrolysis.